A NOVEL SERIES OF MILBEMYCIN ANTIBIOTICS FROM STREPTOMYCES STRAIN-E225 .2. ISOLATION, CHARACTERIZATION, STRUCTURE ELUCIDATION AND SOLUTION CONFORMATIONS

被引：23

作者：

BAKER, GH ^{[1
]}

DORGAN, RJJ ^{[1
]}

EVERETT, JR ^{[1
]}

HOOD, JD ^{[1
]}

POULTON, ME ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,DIV RES,GREAT BURGH,YEW TREE BOTTOM RD,EPSOM KT18 5XQ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 09期

关键词：

D O I：

10.7164/antibiotics.43.1069

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel series of milbemycin antibiotics were isolated from the fermentation broth of a Streptomyces species designated E225. The structures of the four main metabolites VM 44857 (1), VM 44864 (2), VM 44865 (3) and VM 44866 (4) were determined by NMR techniques. In addition we describe the solution conformations of the major metabolite VM 44857 (1). © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：1069 / 1076

页数：8

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