WHY DO CANCER-CELLS HAVE SUCH A HIGH GLYCOLYTIC RATE

被引：55

作者：

ARGILES, JM

LOPEZSORIANO, FJ

机构：

[1] Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, 08071 Barcelona

来源：

MEDICAL HYPOTHESES | 1990年 / 32卷 / 02期

关键词：

D O I：

10.1016/0306-9877(90)90039-H

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The high glycolytic rate of most tumor cells has puzzled biochemists for a long time. In the tumor, glucose is aerobically converted to lactate in the cytoplasm rather than being oxidized in the mitochondria. The molecular mechanisms underlying this phenomenon are still fragmentary. The present study supports the view that the origin of the glucose disposal by the tumor is multifactorial. © 1990.

引用

页码：151 / 155

页数：5

共 32 条

[1]

ARGILES JM, 1988, MOL CELL BIOCHEM, V81, P3

[2]

BRANDT RB, 1984, P SOC EXP BIOL MED, V175, P328

[3] MITOCHONDRIAL HEXOKINASE OF RAT HEPATOMA-CELLS IN CULTURE - SOLUBILIZATION AND KINETIC-PROPERTIES [J].