MUTUALLY EXCLUSIVE BLOCKAGE OF SODIUM-CHANNELS OF MYELINATED FROG NERVE-FIBERS BY BENZOCAINE AND THE INDOLE ALKALOID ERVATAMINE

被引：11

作者：

PICHON, Y

SCHMIDTMAYER, J

ULBRICHT, W

机构：

[1] UNIV KIEL, INST PHYSIOL, D-2300 KIEL 1, FED REP GER

[2] CNRS, NEUROPHYSIOL CELLULAIRE LAB, F-91190 GIF SUR YVETTE, FRANCE

来源：

NEUROSCIENCE LETTERS | 1981年 / 22卷 / 03期

关键词：

D O I：

10.1016/0304-3940(81)90127-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In frog [Rana esculenta] nerve fibers the indole alkaloid ervatamine [found in Ervatamia orientalis] blocks Na+ channels in a frequency-dependent fashion as studied in voltage clamp experiments. In the presence of ervatamine (3 .mu.M), adding or taking away benzocaine (0.5 mM) leads to a non-monotonic further increase or relief of block. This strong interaction is interpreted as competition of the 2 drugs for the same binding site, the receptor of classical local anesthetics.

引用

页码：325 / 330

页数：6

共 20 条

[1] BLOCK OF SODIUM CONDUCTANCE AND GATING CURRENT IN SQUID GIANT-AXONS POISONED WITH QUATERNARY STRYCHNINE [J].