SUPPRESSED SERUM AND URINE LEVELS OF INDOXYL SULFATE BY ORAL SORBENT IN EXPERIMENTAL UREMIC RATS

被引：54

作者：

NIWA, T ^{[1
]}

MIYAZAKI, T ^{[1
]}

HASHIMOTO, N ^{[1
]}

HAYASHI, H ^{[1
]}

ISE, M ^{[1
]}

UEHARA, Y ^{[1
]}

MAEDA, K ^{[1
]}

机构：

[1] KUREHA CHEM IND CO LTD,TOKYO,JAPAN

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1992年 / 12卷 / 04期

关键词：

ORAL SORBENT; AST-120; INDOXYL SULFATE; HIPPURIC ACID; UREMIA;

D O I：

10.1159/000168447

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In uremic patients, the serum concentration of indoxyl sulfate is markedly increased. To determine if oral sorbent (AST-120) suppresses the endogenous synthesis of indoxyl sulfate, it was administered to experimental uremic rats, and the serum concentration and urinary excretion of indoxyl sulfate were quantified by high-performance liquid chromatography. Oral sorbent decreased both the serum concentration and urinary excretion of indoxyl sulfate, suggesting that there was suppression of the endogenous synthesis of indoxyl sulfate by the oral sorbent. Oral sorbent did not decrease the serum concentration and urinary excretion of hippuric acid, but it did alleviate the deterioration of renal function in the experimental uremic rats.

引用

页码：201 / 206

页数：6

共 16 条

[1] DECREASED DRUG-BINDING IN UREMIA - EFFECT OF INDOXYL SULFATE AND OTHER ENDOGENOUS SUBSTANCES ON THE BINDING OF DRUGS AND DYES TO HUMAN-ALBUMIN [J].