HYPOTHALAMIC NEUROPEPTIDE-Y DISTURBANCES IN THE OBESE (CP/CP) JCR-LA CORPULENT RAT

被引:59
作者
WILLIAMS, G [1 ]
SHELLARD, L [1 ]
LEWIS, DE [1 ]
MCKIBBIN, PE [1 ]
MCCARTHY, HD [1 ]
KOESLAG, DG [1 ]
RUSSELL, JC [1 ]
机构
[1] UNIV ALBERTA,DEPT SURG,EDMONTON T6G 2E1,ALBERTA,CANADA
关键词
NEUROPEPTIDE-Y; HYPOTHALAMUS; OBESITY; JCR-LA CORPULENT RAT;
D O I
10.1016/0196-9781(92)90085-H
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Regional hypothalamic neuropeptide Y (NPY) concentrations were compared between cp/cp JCR:LA corpulent rats, which were grossly obese, hyperphagic, and hyperinsulinemic, and lean (+/+) controls. In freely fed cp/cp rats, NPY levels in the arcuate nucleus (ARC) were 31 % higher than in lean rats (p < 0.001). In lean rats, chronic food restriction significantly raised NPY levels by 22% in the ARC (p < 0.05) and by 44% in the dorsomedial nucleus (DMH; p < 0.05). By contrast, food-restricted cp/cp rats showed no change in the ARC, but NPY levels rose in the DMH (by 36%; p < 0.05) and ventromedial nucleus (31 %; p < 0.05). Increased NPY levels in the ARC, the major site of hypothalamic NPY synthesis, suggests increased NPYergic activity in cp/cp rats; given the central actions of NPY, this could contribute to hyperphagia, obesity, and hyperinsulinemia in this syndrome. Abnormal NPY responses to food deprivation further suggest dysregulation of NPY in cp/cp rats.
引用
收藏
页码:537 / 540
页数:4
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