DETERMINATION OF TENOXICAM IN HUMAN PLASMA USING SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET DETECTION

被引：14

作者：

CARLUCCI, G ^{[1
]}

MAZZEO, P ^{[1
]}

PALUMBO, G ^{[1
]}

机构：

[1] UNIV LAQUILA,CATTEDRA FARMACOL,DIPARTIMENTO MED INTERNA & SANITA PUBBL,I-67100 LAQUILA,ITALY

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1992年 / 15卷 / 04期

关键词：

D O I：

10.1080/10826079208018826

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive, specific and rapid liquid chromatographic procedure to selectively monitor tenoxicam in human plasma was developed and validated. Plasma samples were acidified and extracted using solid-phase exctration column. The procedure was linear from 0.1 to 10-mu-g/ml with a detection limit of 0.05-mu-g/ml. The coefficient of variation for the procedure is 6.2% and 2.0% for the range of concentrations examinated. This method is suitable for pharmacological, toxicological and pharmacokinetic studies of tenoxicam.

引用

页码：683 / 695

页数：13

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