MOLECULAR EVOLUTION OF THE HUMAN INTERLEUKIN-8 RECEPTOR GENE-CLUSTER

被引：126

作者：

AHUJA, SK

OZCELIK, T

MILATOVITCH, A

FRANCKE, U

MURPHY, PM

机构：

[1] NIAID,HOST DEF LAB,BETHESDA,MD 20892

[2] STANFORD UNIV,MED CTR,HOWARD HUGHES MED INST,STANFORD,CA 94305

[3] STANFORD UNIV,MED CTR,DEPT GENET,STANFORD,CA 94305

[4] STANFORD UNIV,MED CTR,DEPT PEDIAT,STANFORD,CA 94305

来源：

NATURE GENETICS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1038/ng0992-31

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Interleukin-8 (IL-8) is the prototype for a family of at least eight neutrophil chemoattractants whose genes map to human chromosome 4q13-q21. Two human IL-8 receptors, IL8RA and IL8RB, are known from cDNA cloning; IL8RA is a promiscuous receptor for at least two other related ligands, GRO-alpha and NAP-2. We now report cloning of the genes for IL8RA, IL8RB and a recently inactivated pseudogene of receptor A (IL8RAP). These form a cluster of only three genes in the superfamily of G protein-coupled receptors (GPCRs) and map to 2q34-q35. The coevolutionary diversity displayed by the IL-8 ligand-receptor complex - ligand promiscuity for IL-8, receptor promiscuity for IL8RA, gene duplication for both ligands and receptors and gene extinction in the case of IL8RAP - is unprecedented for the GPCR superfamily.

引用

页码：31 / 36

页数：6

共 46 条

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