THE USE OF BOTULINUM TOXIN IN THE TREATMENT OF ADDUCTOR SPASMODIC DYSPHONIA

被引：42

作者：

WHURR, R

LORCH, M

FONTANA, H

BROOKES, G

LEES, A

MARSDEN, CD

机构：

[1] NATL HOSP NEUROL & NEUROSURG,LONDON,ENGLAND

[2] NATL HOSP,INST NEUROL,LONDON WC1N 3BG,ENGLAND

[3] UNIV LONDON BIRKBECK COLL,LONDON WC1E 7HX,ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1993年 / 56卷 / 05期

关键词：

D O I：

10.1136/jnnp.56.5.526

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the fundamental frequency of the speech sample, indicating a reduction in the variability of pitch amongst patients. A total of 96% of patients' subjective diary reports showed an improvement with a median of 7 days to peak effect and a 5 week duration of peak effect.

引用

页码：526 / 530

页数：5

共 26 条

[1]

ARONSON AE, 1983, LARYNGOSCOPE, V93, P1

[2]

BECK K, 1918, PASSOWSCHAEFER BEITR, V11, P130

[3]

Berendes J, 1938, Z HALS NASEN OHRENH, V44, P78

[4] LARYNGEAL DYSTONIA - A SERIES WITH BOTULINUM TOXIN THERAPY [J].