ANALYSIS OF THE 5-HT(1C) RECEPTOR AND THE SEROTONIN UPTAKE SITE IN FAWN-HOODED RAT-BRAIN

被引：23

作者：

HULIHANGIBLIN, BA

PARK, YD

GOLDMAN, D

AULAKH, CS

机构：

[1] NIAAA,NEUROGENET LAB,BETHESDA,MD 20892

[2] NIAAA,CLIN SCI LAB,BETHESDA,MD 20892

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 239卷 / 1-3期

关键词：

H-3]MESULERGINE; H-3]PAROXETINE; 5-HT(1C) RECEPTOR; 5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); 5-HT UPTAKE SITE; BRAIN (RAT);

D O I：

10.1016/0014-2999(93)90981-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Both the 5-HT1C receptor and the 5-HT uptake binding sites were measured in Fawn-Hooded, Sprague-Dawley and Wistar rats. Five brain regions were examined: frontal cortex, hippocampus, striatum, hypothalamus, and brainstem. We found significant differences in the B(max) and K(d) values in various brain regions comparing Fawn-Hooded rats, with Sprague-Dawley and Wistar animals. The regional differences in receptor number and affinity in both the 5-HT1C receptor and the 5-HT uptake site in the Fawn-Hooded strain, relative to Wistar and Sprague-Dawley animals, provide support for the use of the Fawn-Hooded rat in serotonin dysfunction studies.

引用

页码：99 / 102

页数：4

共 16 条

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[2]

Aulakh C. S., 1989, PHARM BIOCH BEHAV, V31, P567

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