NON-SYNERGISTIC RELAXANT EFFECTS OF VASOACTIVE INTESTINAL POLYPEPTIDE AND SIN-1 IN HUMAN ISOLATED CAVERNOUS ARTERY AND CORPUS CAVERNOSUM

被引：16

作者：

HEMPELMANN, RG

PAPADOPOULOS, I

HERZIG, S

机构：

[1] CHRISTIAN ALBRECHTS UNIV KIEL,DEPT PHARMACOL,D-24105 KIEL,GERMANY

[2] CHRISTIAN ALBRECHTS UNIV KIEL,DEPT UROL,D-24105 KIEL,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 276卷 / 03期

关键词：

NITRIC OXIDE (NO); SIN-1 (3-MORPHOLINO-SYDNONIMINE); VIP (VASOACTIVE INTESTINAL POLYPEPTIDE); CAVERNOUS ARTERY; SMOOTH MUSCLE; CAVERNOSAL; (HUMAN);

D O I：

10.1016/0014-2999(95)00081-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since vasoactive intestinal peptide (VIP) and nitric oxide (NO) are considered to be non-adrenergic, non-cholinergic (NANC) inhibitory mediators in human penile erectile tissue, the goal of this study was to discover possible synergistic effects of exogeneous VIP and the NO donor 3-morpholino-sydnonimine (SIN-1) in human isolated cavernous arteries and cavernosal smooth muscle. In contrast to VIP, SIN-1 elicited complete and reproducible relaxant actions. Combined administration of VIP and SIN-1 revealed non-synergistic, independent relaxant effects in both investigated tissues. The results do not favour a combined administration of VIP and SIN-1 as a new therapeutic approach in the treatment of erectile dysfunction.

引用

页码：277 / 280

页数：4

共 14 条

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ANDERSON KE, 1993, PHARMACOL REV, V45, P253

[2]

ARIENS EJ, 1956, ARZNEIMITTEL-FORSCH, V6, P737

[3] ENDOTHELIUM-DERIVED NITRIC-OXIDE AND CYCLOOXYGENASE PRODUCTS MODULATE CORPUS CAVERNOSUM SMOOTH-MUSCLE TONE [J].