SUPPRESSION OF HIV REPLICATION BY CD8(+) CELL CLONES DERIVED FROM HIV-INFECTED AND UNINFECTED INDIVIDUALS

被引：41

作者：

HSUEH, FW

WALKER, CM

BLACKBOURN, DJ

LEVY, JA

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT MED,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,SCH MED,CANC RES INST,SAN FRANCISCO,CA 94143

来源：

CELLULAR IMMUNOLOGY | 1994年 / 159卷 / 02期

关键词：

D O I：

10.1006/cimm.1994.1313

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CD8(+) cell clones have been derived from peripheral blood mononuclear cells of human immunodeficiency virus (HIV)-infected and uninfected individuals. Several of these cloned cells have the ability to suppress HIV replication when cocultured with CD4(+) cells acutely infected in the laboratory with HIV or with infected CD4(+) cells from infected subjects. Suppression of virus production occurs without killing the target cells. With the CD8(+) cell clones studied, this antiviral response correlated with production of a filterable factor that has antiviral activity. These cell clones offer the opportunity for identification of the factor mediating suppression of HIV replication. Moreover, adoptive transfer of cell clones might provide a valuable therapeutic approach for HIV-infected individuals. (C) 1994 Academic Press, Inc.

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页码：271 / 279

页数：9

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