IN-SITU POLYMERIZATION OF PYRROLE IN ANIMAL TISSUE IN THE FORMATION OF HYBRID BIOMATERIALS

被引：16

作者：

KHOR, E ^{[1
]}

LI, HC ^{[1
]}

WEE, A ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,DEPT PATHOL,SINGAPORE 0511,SINGAPORE

来源：

BIOMATERIALS | 1995年 / 16卷 / 08期

关键词：

POLYPYRROLE; ANIMAL TISSUE; HYBRID BIOMATERIALS;

D O I：

10.1016/0142-9612(95)93864-A

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Porcine pericardium was impregnated with pyrrole or its derivative, sodium 4-(3-pyrrolyl)butanesulphonate (SPBS), by soaking the animal tissue in the monomer. Subsequent in situ chemical polymerization of the monomer-rich tissue using FeCl3 as initiator produced black polypyrrole-tissue hybrid biomaterials. The rate and extent of polymerization was found to be greater in 0.5 M acetic acid than in Hepes-buffered saline (HBS) and also greater for SPBS than for pyrrole. However, better tissue integrity was obtained for polymerization in HBS. Histological examination showed that the monomers do not permeate through the entire tissue, restricting polymerization to the surface layers of the tissue. The samples so formed do not exhibit detectable electrical conductivity.

引用

页码：657 / 661

页数：5

共 7 条

[1]

GIUSTI P, 1993, TRENDS POLYM SCI, V1, P261

[2]

GOTT VL, 1961, SURGERY, V50, P382

[3] Water-Soluble Self-Doped 3-Substituted Polypyrroles [J].

Havinga, E. E. ;

ten Hoeve, W. ;

Meijer, E. W. ;

Wynberg, H. .

CHEMISTRY OF MATERIALS, 1989, 1 (06) :650-659

[4] REGIOSELECTIVE SYNTHESIS OF ACYLPYRROLES [J].

KAKUSHIMA, M ;

HAMEL, P ;

FRENETTE, R ;

ROKACH, J .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (19) :3214-3219

[5] INTERACTION OF COLLAGEN WITH POLYPYRROLE IN THE PRODUCTION OF HYBRID MATERIALS [J].

LI, HC ;

KHOR, E .

POLYMER INTERNATIONAL, 1994, 35 (01) :53-59

[6]

LI HC, IN PRESS MACROMOL CH

[7] ELECTRICALLY CHARGED POLYMERIC SUBSTRATES ENHANCE NERVE-FIBER OUTGROWTH INVITRO [J].

VALENTINI, RF ;

VARGO, TG ;

GARDELLA, JA ;

AEBISCHER, P .

BIOMATERIALS, 1992, 13 (03) :183-190

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