TREATMENT OF MYOCARDIAL INFARCTION WITH LOW MOLECULAR WEIGHT DEXTRAN

A total of 110 cases of acute myocardial infarction were randomized into two groups. Group A received standard therapy plus 5 per cent glucose in water, 500 c.c. in the first four hours, then 500 c.c. every eight hours for 72 hours. Group B received standard therapy plus 10 per cent LMDx in 5 per cent glucose, 500 c.c. in the first four hours, then 500 c.c. every eight hours for 72 hours. A total of 65 cases fell into Group A and 45 cases in Group B. There were no complications from the LMDx therapy. The mortality rate in Group A was 32.3 per cent and in Group B was 13.3 per cent. The probability of this variance occurring by chance is less than 3 per cent. The problems associated with dosage control have been presented. © 1968.