DETERMINATION OF MOLSIDOMINE IN PLASMA BY HIGH-PERFORMANCE LIQUID COLUMN CHROMATOGRAPHY

被引：28

作者：

DELL, D

CHAMBERLAIN, J

机构：

[1] Hoechst Pharmaceutical Research Laboratories, Walton Manor, Milton Keynes,, Buckinghamshire Buckinghamshire, Walton

来源：

JOURNAL OF CHROMATOGRAPHY | 1978年 / 146卷 / 03期

关键词：

D O I：

10.1016/S0378-4347(00)81205-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method is described for the analysis of the anti-anginal compound 5-ethoxycarbonyl-3-morpholinosydnonimine (Molsidomine) in human and dog plasma. The drug was extracted from plasma into chloroform and the analysis was carried out on a reversed-phase column, the column effluent being monitored by UV absorption at 312 nm. The method is sensitive (2 ± 0.3 ng/ml) and specific. The method was applied to a study in which human volunteers received an aqueous solution of the drug and then, on a separate occasion, a tablet formulation. Peak plasma levels of 20-30 ng/ml (tablet) and 10-19 ng/ml (aqueous solution) were obtained following a 2-mg oral dose. © 1978.

引用

页码：465 / 472

页数：8