SPONTANEOUS DIABETES IN BB RATS - EVIDENCE FOR INSULIN-DEPENDENT LIVER MICROSOMAL DELTA-6 AND DELTA-5 DESATURASE ACTIVITIES

被引：16

作者：

MIMOUNI, V ^{[1
]}

POISSON, JP ^{[1
]}

机构：

[1] FAC SCI MIRANDE,PHYSIOL ANIM & NUTR LAB,BP 138,F-21004 DIJON,FRANCE

来源：

HORMONE AND METABOLIC RESEARCH | 1990年 / 22卷 / 08期

关键词：

BB rats; fatty acids; insulin; liver; microsomes; spontaneous diabetes; Δ5; desaturase; Δ6;

D O I：

10.1055/s-2007-1004934

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied linoleic acid Δ5 and dihomo-γ-linolenic acid Δ5 desaturations, and fatty acid composition, of liver microsomes in the insulin-dependent spontaneously diabetic adult female BB rat. These desaturations were defective along the normo- and hyper-glycemic period and restored during the hypoglycemic period which followed the insulin injection to the diabetic rats. The fatty acid composition of BB rat microsomes was not consistent with the desaturase activities at the different periods of glycemia, probably because other factors than desaturation impairments were involved in the evolution of fatty acid composition

引用

页码：405 / 407

页数：3

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