SIDE-EFFECTS OF DIPHTHERIA-TETANUS TOXOID IN ADULTS

被引:36
作者
MIDDAUGH, JP
机构
关键词
D O I
10.2105/AJPH.69.3.246
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
During a mass diphtheria-tetanus immunization campaign in November 1975, more than 220,000 doses of diphtheria-tetanus toxoid, adult type were administered to adults throughout Alaska. In Anchorage, where more than 87,000 doses were given, a survey was conducted to determine the frequency of side effects. Postcard questionnaires were mailed to 2,000 randomly selected Anchorage residents; 467 questionnaires were returned by the post office as undeliverable, and 697 questionnaires were completed and returned. A follow-up survey was done of a random sample of the 836 non-responders. Of those responding, 57.8% reported at least 1 reaction to the toxoids. The most frequent side effects were sore arm (42.7%), swelling at the site of injection (34.8%), and itching (24.2%). Serious side effects occurred less frequently - swelling of the arm below the elbow (1.1%) and abscess or infection (0.7%). Of those vaccinated, 05.% saw a physician. There were no statistically significant differences in reaction rates by age group, except for sore arms. The jet injector produced more arm swelling at the site of injection, hives, and itching. More women than men reported adverse reactions, especially sore arm, swelling at the site of injection, and itching. Fear of adverse side effects should not preclude mass vaccination of adults.
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页码:246 / 249
页数:4
相关论文
共 13 条
[1]  
EDSALL G, 1954, AM J PUBLIC HEALTH, V44, P1537
[2]   IMMUNIZATION AGAINST TETANUS AND DIPHTHERIA WITH SPECIAL COMBINED TOXOID [J].
GRAHAM, BS ;
BLUM, HL ;
GREEN, TW .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1958, 166 (13) :1586-1588
[3]   DIPHTHERIA OUTBREAK IN DADE COUNTY, FLORIDA [J].
HENNEKENS, CH ;
SASLAW, MS .
SOUTHERN MEDICAL JOURNAL, 1976, 69 (06) :759-&
[4]   IMMUNIZATION OF ADULTS AGAINST DIPHTHERIA AND TETANUS [J].
IPSEN, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1954, 251 (12) :459-466
[5]   ADULT IMMUNIZATION - PREPARATION AND EVALUATION OF COMBINED FLUID TETANUS AND DIPHTHERIA TOXOIDS FOR ADULT USE [J].
LEVINE, L ;
IPSEN, J ;
MCCOMB, JA .
AMERICAN JOURNAL OF HYGIENE, 1961, 73 (01) :20-+
[6]   15TH ANNIVERSARY OF DIPHTHERIA AND TETANUS IMMUNIZATION [J].
LEVY, FM .
PREVENTIVE MEDICINE, 1975, 4 (02) :226-237
[7]   DIPHTHERIA IMMUNIZATION - EFFECT UPON CARRIERS AND CONTROL OF OUTBREAKS [J].
MILLER, LW ;
ZIMMERMAN, S ;
DRAKE, J ;
OLDER, JJ .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1972, 123 (03) :197-+
[8]  
PAPPENHEIMER AM, 1950, AM J HYG, V52, P323
[9]  
SCHEIBEL I, 1948, ACTA PATHOL MIC SC, V25, P319
[10]  
SCHEIBEL I, 1950, ACTA PATHOL MIC SC, V27, P69