REGULATION OF DISSOLUTION RATE BY PELLET GEOMETRY

被引：30

作者：

RIPPIE, EG

JOHNSON, JR

机构：

[1] Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 04期

关键词：

Colorimetric analysis—spectrophotometer; Dissolution rate—pellet geometry effect; Extrusion process—pellet formation; Pellet surface area—dissolution effect;

D O I：

10.1002/jps.2600580408

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The influence of surface configuration on the dissolution behavior of pellets suspended in a turbulent flow field has been investigated. The rate of dissolution of extruded cellulose acetate hydrogen phthalate pellets was found to be a complex function of surface geometry. The study was undertaken to determine the in vitro sustained release characteristics of pellets of a form such that their loss of effective surface area during dissolution is minimized. Factors involved in the design of such pellets are discussed and data are presented which indicate the dissolution characteristics of test forms. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：428 / &

共 10 条

[1]

BALLARD BE, 1962, J PHARMACOL EXP THER, V135, P120

[2]

COWIE AT, 1944, J ENDOCRINOL, V4, P375

[3] Absorption of pellets of crystalline testosterone, testosterone propionate, methyl testosterone, progesterone, desoxycorticosterone and stilbestrol implanted in the rat [J].