CELL-SURFACE COMPONENT(S) INVOLVED IN RAT HEPATOCYTE INTER-CELLULAR ADHESION

被引：24

作者：

OBRINK, B

OCKLIND, C

机构：

[1] Department of Medical and Physiological Chemistry, University of Uppsala, The Biomedical Center, S-751 23 Uppsala

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 85卷 / 02期

关键词：

D O I：

10.1016/0006-291X(78)91238-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aggregation of rat hepatocytes was effectively inhibited by monovalent antibodies (Fab fragments) directed against hepatocyte plasma membranes, but monovalent antibodies against some distinct, known hepatocyte surface antigens had no effect. Surface antigens, which neutralized the Fab inhibiting effect on cell aggregation, could be solubilized from plasma membranes by limited proteolytic digestion. Thus, hepatocyte intercellular adhesion seems to involve specific cell surface components, which may be proteins or protein derivatives. © 1978.

引用

页码：837 / 843

页数：7

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