MAJOR DETERMINANTS OF THE SPECIFICITY OF INTERACTION BETWEEN SMALL NUCLEAR RIBONUCLEOPROTEIN-U1A AND RIBONUCLEOPROTEIN-U2B'' AND THEIR COGNATE RNAS

被引：263

作者：

SCHERLY, D ^{[1
]}

BOELENS, W ^{[1
]}

DATHAN, NA ^{[1
]}

VANVENROOIJ, WJ ^{[1
]}

MATTAJ, IW ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,6500 HB NIJMEGEN,NETHERLANDS

来源：

NATURE | 1990年 / 345卷 / 6275期

关键词：

D O I：

10.1038/345502a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The basis of the specificity of interaction of Ul and U2 small nuclear (sn)RNAs and their cognate binding proteins, U1A and U2B″, has been examined. The U1A protein recognizes Ul snRNA on its own, whereas U2B″ binds specifically to U2 snRNA only in the presence of a second protein, U2A'. Exchange of two nucleotides between the two RNAs or of eight amino acids between the two proteins reverses binding specificity. © 1990 Nature Publishing Group.

引用

页码：502 / 506

页数：5

共 31 条

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