CARCINOGENIC EFFECT OF N-BIS(2-HYDROXYPROPYL)NITROSAMINE BY A SINGLE ADMINISTRATION IN RATS

被引：12

作者：

KONISHI, Y ^{[1
]}

IKEDA, T ^{[1
]}

YOSHIMURA, H ^{[1
]}

KAWABATA, A ^{[1
]}

MIKAMI, R ^{[1
]}

机构：

[1] NARA MED UNIV,DEPT INTERNAL MED 2,KASHIHARA,NARA 634,JAPAN

来源：

CANCER LETTERS | 1979年 / 6卷 / 02期

关键词：

D O I：

10.1016/S0304-3835(79)80009-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The carcinogenic effect of a single intraperitoneal injection of N-bis(2-hydroxypropyl)nitrosamine (BHP) was studied in male Wistar rats. Lung tumors (adenomas and adenocarcinomas) had the highest incidence (100%). Fewer neoplasms were induced in the thyroid (adenomas and adenocarcinomas, 36%), kidney (renal cell carcinomas, 8%), and the sigmoid colon (adenomas and adenocarcinomas, 9%). No pancreatic neoplasms were found. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：115 / 119

页数：5

共 11 条

[1] ORGANOTROPE CARCINOGENE WIRKUNGEN BEI 65 VERSCHIEDENEN N-NITROSO-VERBINDUNGEN AN BD-RATTEN [J].

DRUCKREY, H ;

PREUSSMA.R ;

IVANKOVI.S ;

SCHMAHL, D ;

AFKHAM, J ;

BLUM, G ;

MENNEL, HD ;

MULLER, M ;

PETROPOU.P ;

SCHNEIDE.H .

ZEITSCHRIFT FUR KREBSFORSCHUNG, 1967, 69 (02) :103-&

[2]

KONISHI Y, 1978, GANN, V69, P573

[3]

KONISHI Y, 1976, GANN, V67, P773

[4] CARCINOGENIC EFFECT OF N-BIS (2-HYDROXYPROPYL)-NITROSAMINE BY ORAL-ADMINISTRATION IN MICE [J].

KONISHI, Y ;

KONDO, H ;

INUI, S ;

DENDA, A ;

IKEDA, T ;

KOJIMA, K .

CANCER LETTERS, 1977, 3 (5-6) :255-257

[5]

KRUGER FW, 1974, NATURWISSENSCHAFTEN, V61, P328

[6] CARCINOGENIC EFFECTS OF DI-ISOPROPANOLNITROSAMINE IN SPRAGUE-DAWLEY RATS [J].

MOHR, U ;

REZNIK, G ;

POUR, P .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 58 (02) :361-366

[7] CARCINOGENIC EFFECT OF DI-N-PROPYLNITROSAMINE IN SYRIAN GOLDEN-HAMSTERS [J].

POUR, P ;

KRUGER, FW ;

CARDESA, A ;

ALTHOFF, J ;

MOHR, U .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (03) :1019-1027

[8]

POUR P, 1974, AM J PATHOL, V76, P349

[9]

POUR P, 1975, CANCER, V36, P379, DOI 10.1002/1097-0142(197508)36:2<379::AID-CNCR2820360213>3.0.CO

[10]

2-R

← 1 2 →