COLONY-FORMING EFFICIENCY RESPONSE OF BONE-MARROW STROMAL CELLS TO ACUTE BLOOD-LOSS

被引：27

作者：

LIPPIELLO, L ^{[1
]}

CHAVDA, D ^{[1
]}

CONNOLLY, J ^{[1
]}

机构：

[1] ORLANDO REG MED CTR INC,ORLANDO,FL

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 1992年 / 10卷 / 01期

关键词：

MARROW OSTEOGENESIS; COLONY-FORMING EFFICIENCY; STROMAL CELLS; OSTEOPOIETIN;

D O I：

10.1002/jor.1100100117

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Colony-forming efficiency (CFE) was used to monitor the proliferative response of alkaline phosphatase-positive rabbit bone marrow stromal cells to acute blood loss. The CFE of animals subjected to a 1% blood loss was 0.97 compared with 0.06 (p < 0.01) in nonbled animals. Sera obtained from animals 10 days after an initial blood loss stimulated the CFE of marrow cultures from nonbled donors to the same degree as osteogenin. Erythropoietin and control sera (from nonbled animals) had no effect. Hence, acute blood loss and sera from bled animals stimulate proliferation of alkaline phosphatase-positive marrow stromal cell colonies. The agent(s) responsible is unknown but it is present in serum in response to blood loss. Confirmation of a specific effect on osteoprogenitor cells may warrant the designation "osteopoietin."

引用

页码：145 / 148

页数：4

共 11 条

[1] IDENTIFICATION IN ADULT BONE-MARROW OF PLURIPOTENT AND RESTRICTED STEM-CELLS OF MYELOID AND LYMPHOID SYSTEMS [J].