THE INTRINSIC ALPHA BETA RATIO FOR HUMAN TUMOR-CELLS - IS IT A CONSTANT

被引:35
作者
PEACOCK, JH
EADY, JJ
EDWARDS, SM
MCMILLAN, TJ
STEEL, GG
机构
[1] Radiotherapy Research Unit, Institute of Cancer Research, Sutton, Surrey
关键词
D O I
10.1080/09553009214551241
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation. As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (termed alpha(ac) and beta(ac)low dose-rate and split-dose experiments have been used to derive independent values of alpha and beta (alpha(ldr) and beta(RR)) respectively. alpha(ldr) provides a measure of irrecoverable damage, the magnitude of which agreed well with the initial slope of the acute survival curve for most cell lines. beta(RR) derived from split-dose experiments represents a unique measure of recovery for each cell line. Large differences were found between individual values of beta(ac) and beta(RR), especially in the radiosensitive cell lines. Since beta(RR) is a functional measure of recovery we suggest that this is the more relevant parameter in studies of dose sparing. The most striking result of this analysis was found in considering the alpha/beta ratios. No relationship was observed between alpha(ac) and beta(ac) resulting in values of alpha(ac)/beta(ac) ranging from 1 to 175. In contrast a positive correlation was observed between alpha(ldr) and beta(RR) in the 11 tumour cell lines, giving an alpha/beta ratio of 9.4 +/- 1.8 Gy. This observation of the relative constancy of the ratio for human tumour cells leads to an hypothesis about the role of initial damage as a determinant of radiosensitivity.
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页码:479 / 487
页数:9
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