NICOTINIC CHOLINOCEPTIVE NEURONS OF THE FRONTAL-CORTEX ARE REDUCED IN ALZHEIMERS-DISEASE

被引：144

作者：

SCHRODER, H

GIACOBINI, E

STRUBLE, RG

ZILLES, K

MAELICKE, A

机构：

[1] SO ILLINOIS UNIV,SCH MED,CTR ALZHEIMERS DIS & RELATED DISORDERS,SPRINGFIELD,IL 62708

[2] SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL,SPRINGFIELD,IL 62708

[3] SO ILLINOIS UNIV,SCH MED,DEPT PATHOL PSYCHIAT,SPRINGFIELD,IL 62708

来源：

NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 03期

关键词：

ALZHEIMERS DISEASE; NICOTINIC ACETYLCHOLINE RECEPTORS; HUMAN CEREBRAL CORTEX; IMMUNOCYTOCHEMISTRY; AGING; MORPHOMETRY;

D O I：

10.1016/0197-4580(91)90107-U

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex (area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged controls using the monoclonal antibody WF 6 and an immunoperoxidase protocol. Statistical analysis revealed significant differences between the number of labeled neurons among all three groups tested (middle-aged controls > aged controls > Alzheimer cases). No differences were seen for cresyl violet-stained samples. These findings underline that the nicotinic receptor decrease found with radioligand binding may reflect a postsynaptic in addition to a presynaptic component.

引用

页码：259 / 262

页数：4

共 27 条

[1] BILATERAL CHANGES IN NEOCORTICAL [H-3]PIRENZEPINE AND [H-3] OXOTREMORINE-M BINDING FOLLOWING UNILATERAL LESIONS OF THE RAT NUCLEUS BASALIS MAGNOCELLULARIS - AN AUTORADIOGRAPHIC STUDY [J].