ENANTIOMERIC SEPARATION OF AMINO-ALCOHOLS ON DINITROBENZOYL-DIAMINOCYCLOHEXANE CHIRAL STATIONARY PHASES

被引：8

作者：

GALLINELLA, B

LATORRE, F

CIRILLI, R

VILLANI, C

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO STUDI CHIM & TECHNOL SOSTANZE BIOLOGICAMENTE ATT,I-00185 ROME,ITALY

[2] IST SUPER SANITA,CHIM FARM LAB,I-00185 ROME,ITALY

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 639卷 / 02期

关键词：

D O I：

10.1016/0021-9673(93)80254-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A silica-bonded chiral stationary phase, containing the N,N'-3,5-dinitrobenzoyl derivative of 1R,2R-diaminocyclohexane, was used to separate the enantiomers of some amino alcohols with beta-blocking activity after their conversion to oxazolidin-2-ones. The influence of mobile phase composition (mixtures of hexane with dichloromethane, chloroform, dioxane and isopropanol) on the enantioselectivity and efficiency of the column was evaluated. Furthermore, a tandem arrangement of the chiral column and its racemic version was used to resolve all the stereoisomers of one amino alcohol containing two stereogenic centres.

引用

页码：193 / 196

页数：4

共 13 条

[1]

Allen S E, 1989, CHIRAL SEPARATIONS H, P285

[2] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON CHIRAL PACKED MICROBORE COLUMNS WITH THE 3,5-DINITROBENZOYL DERIVATIVE OF TRANS-1,2-DIAMINOCYCLOHEXANE AS SELECTOR [J].