POSTOPERATIVE ELEVATION OF SERUM TRANSAMINASES FOLLOWING ISOFLURANE ANESTHESIA

被引：20

作者：

GUNZA, JT

PASHAYAN, AG

机构：

来源：

JOURNAL OF CLINICAL ANESTHESIA | 1992年 / 4卷 / 04期

关键词：

D O I：

10.1016/0952-8180(92)90143-O

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Halogenated inhalational anesthetics have been implicated in hepatotoxicity. Halothane hepatitis results from the biotransformation of the drug to a metabolite that binds to liver proteins, which creates a hapten, which, in turn, causes an immunologic response in the liver. Case reports of hepatic injury resulting from isoflurane, which has a decreased biotransformation compared with that of halothane, have received much criticism. We describe a patient who had elevated liver enzymes and a positive trifluoroacetyl antibody titer following an anesthetic regimen that included isoflurane.

引用

页码：336 / 341

页数：6