BUCCAL DELIVERY SYSTEMS USING HYDROGELS

被引：59

作者：

NAGAI, T ^{[1
]}

MACHIDA, Y ^{[1
]}

机构：

[1] HOSHI UNIV,DEPT PHARMACEUT,EBARA 2-4-41,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1993年 / 11卷 / 1-2期

关键词：

BUCCAL DELIVERY SYSTEM; KERATINIZED LAYER; PERMEATION ENHANCER; MUCOADHESIVENESS; SUSTAINED RELEASE; TOPICAL DELIVERY; SYSTEMIC DELIVERY; POLYCARBOPHIL; HYDROXYPROPYL CELLULOSE; CARBOPOL; NATURAL GUMS;

D O I：

10.1016/0169-409X(93)90032-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Buccal or oral mucosal routes have various advantages for the administration of drugs which undergo severe first-pass metabolism. Hydrogel seemed an appropriate material for the buccal delivery systems because of its mucoadhesiveness, sustained-release property, good feel in the mouth, and safety. In this review, recent reports on buccal delivery systems using hydrogels developed for topical and systemic drug delivery are introduced after a description of the basic concepts of buccal administration.

引用

页码：179 / 191

页数：13

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