CERAMIC HYDROXYAPATITE IMPLANTS FOR THE RELEASE OF BISPHOSPHONATE

被引:49
作者
DENISSEN, H
VANBEEK, E
LOWIK, C
PAPAPOULOS, S
VANDENHOOFF, A
机构
[1] LEIDEN UNIV HOSP,DEPT ENDOCRINOL,2333 AA LEIDEN,NETHERLANDS
[2] UNIV AMSTERDAM,SCH MED,CELL BIOL & HISTOL LAB,AMSTERDAM,NETHERLANDS
来源
BONE AND MINERAL | 1994年 / 25卷 / 02期
关键词
CERAMIC RELEASE SYSTEM; HYDROXYAPATITE; BISPHOSPHONATE;
D O I
10.1016/S0169-6009(08)80254-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Maintaining bone mass after extraction of teeth is a major problem in the prevention of oral disease. Maintenance theoretically could be enhanced by immediate implantation of submerged ceramic hydroxyapatite (HA) implants releasing the bone resorption-inhibiting agent bisphosphonate (P-C-P). Four different types of ceramic HA implants were designed as release systems for an in vitro study and assayed in saline at a temperature of 37 degrees C during 3 months. The implants were either rod- or tube-shaped, with densities of 3.104 g/cm(3) and 1.408 g/cm(3) (microporous) or 2.369 g/cm(3) (macro/microporous). Loading of the implants with the P-C-P was done by adsorption into the ceramic (rod-shaped implants) or by filling the reservoir of the implant (tube-shaped implants). Despite the fact that P-C-P has a high bonding affinity to HA it appeared that the release of adsorbed P-C-P from the ceramic HA occurred steady, controlled and over a long period of time. The rod-shaped implants had much better release properties than the tube-shaped implants. Microporous ceramic HA rods sintered at 800 degrees C and macro/microporous rods sintered at 1300 degrees C are considered to be promising release systems for P-C-Ps.
引用
收藏
页码:123 / 134
页数:12
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