INFLUENCE OF THE ANESTHETIC 2,6-DIISOPROPYLPHENOL (PROPOFOL) ON ISOLATED RAT-HEART MITOCHONDRIA

被引：30

作者：

BRANCA, D ^{[1
]}

VINCENTI, E ^{[1
]}

SCUTARI, G ^{[1
]}

机构：

[1] UNIV PADUA,IST ANESTESIOL & RIANIMAZ,I-35121 PADUA,ITALY

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1995年 / 110卷 / 01期

关键词：

ATP SYNTHESIS; ATP LYSIS; CALCIUM HOMEOSTASIS; 2,6-DIISOPROPYLPHENOLGENERAL ANESTHETICS; HEART MITOCHONDRIA; OXYGEN CONSUMPTION; RATS; TRANSMEMBRANE POTENTIAL;

D O I：

10.1016/0742-8413(94)00078-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of the anesthetic 2,6-diisopropylphenol on isolated rat heart mitochondria has been investigated at a range of concentrations encompassing high and low clinical values. Low clinical concentrations of the anesthetic appeared unable to affect both oxidative phosphorylation and calcium homeostasis, 2,6-diisopropylphenol at high clinical levels decreased both the transmembrane electrical potential and the synthesis of ATP, while leaving mitochondrial calcium homeostasis unaffected, The results obtained suggest that isolated heart mitochondria are substantially insensitive to low clinical concentrations of 2,6-diisopropylphenol, thus largely excluding the possibility that mitochondrial alterations might be involved in the cardiac depression induced by this anesthetic.

引用

页码：41 / 45

页数：5

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