ENANTIOMERIC PURITY OF NAPROXEN BY LIQUID-CHROMATOGRAPHIC ANALYSIS OF ITS DIASTEREOMERIC OCTYL ESTERS

被引：24

作者：

JOHNSON, DM

REUTER, A

COLLINS, JM

THOMPSON, GF

机构：

[1] Pharmaceutical Analysis Department, Syntex Research, Palo Alto, California

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

关键词：

Anti‐inflammatory agents—naproxen; liquid chromatographic analysis of enantiomers; Enantiomers—of naproxen; liquid chromatographic analysis; Liquid chromatography—analysis; enantiomers of naproxen; Naproxen—liquid chromatographic analysis of enantiomers;

D O I：

10.1002/jps.2600680139

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A sensitive and specific analytical method was developed to determine the enantiomeric purity of naproxen. A simple derivatization of naproxen with (S)‐(+)‐2‐octanol proceeded quantitatively and gave a mixture of diastereomeric esters displaying baseline separation on liquid chromatography. The ratio of these esters was the same as the ratio of enantiomers present in naproxen samples assayed. Reproducibility of the method was excellent. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：112 / 114

页数：3

共 8 条

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