CHOLESTATIC AND HEPATOCELLULAR INJURY ASSOCIATED WITH ERYTHROMYCIN ESTERS - REPORT OF 9 CASES

被引:67
作者
ZAFRANI, ES
ISHAK, KG
RUDZKI, C
机构
[1] ARMED FORCES INST PATHOL,DEPT HEPAT PATHOL,WASHINGTON,DC 20306
[2] GEORGE WASHINGTON UNIV,WASHINGTON,DC 20006
关键词
D O I
10.1007/BF01297126
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A combined cholestatic and hepatocellular injury occurred in nine patients, following therapy with erythromycin estolate (EE) or other erythromycin derivatives. Eight of the nine patients developed jaundice within three weeks after initiation of treatment; pain was one of the main symptoms in five patients while fever and itching were noted in four patients. Symptoms and signs subsided and abnormal tests of liver function returned to normal after withdrawal of the drug. The major histologic finding was cholestasis, but the majority of cases also had evidence of hepatocellular injury of variable severity; one biopsy specimen showed centrilobular necrosis. Ultrastructural findings in one case included changes related to cholestasis as well as hepatocellular injury with striking mitochondrial abnormalities. Our data are compared with those of the literature, with special reference to morphologic features. © 1979 Digestive Disease Systems, Inc.
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页码:385 / 396
页数:12
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