CHARACTERIZATION OF AN IRRITANT 4-DEOXYPHORBOL DIESTER FROM EUPHORBIA-TIRUCALLI

被引：25

作者：

KINGHORN, AD

机构：

[1] Department of Pharmacognosy and Pharmacology, College of Pharmacy, University of Illinois at the Medical Center, Illinois, Chicago

来源：

LLOYDIA-THE JOURNAL OF NATURAL PRODUCTS | 1979年 / 42卷 / 01期

关键词：

D O I：

10.1021/np50001a006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Latex of Euphorbia tirucalli, collected in Colombia, yielded 12-O-2Z-4E-octadienoyl-4-deoxyphorbol-13-acetate (1), which exhibited an irritant potency equivalent to that of the standard irritant, phorbol-12-tetradecanoate-13-acetate, in a mouse ear test system. The unsaturated 4-deoxyphorbol diesters recently reported in E. tirucalli grown in South Africa were not observed in the present study. © 1979, American Chemical Society. All rights reserved.

引用

页码：112 / 115

页数：4

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