URICASE-LIKE CATALYTIC ACTIVITY OF ION-EXCHANGE RESINS MODIFIED WITH METALLOPORPHYRINS

被引：8

作者：

MIFUNE, M

ODO, J

IWADO, A

SAITO, Y

MOTOHASHI, N

CHIKUMA, M

TANAKA, H

机构：

[1] OKAYAMA UNIV,FAC PHARMACEUT SCI,1-1-1 TSUSHIMA NAKA,OKAYAMA 700,JAPAN

[2] KOBE WOMENS COLL PHARM,HIGASHI KU,KOBE 658,JAPAN

[3] OSAKA UNIV PHARMACEUT SCI,MATSUBARA 580,JAPAN

[4] KYOTO PHARMACEUT UNIV,YAMASHINA KU,KYOTO 607,JAPAN

来源：

TALANTA | 1991年 / 38卷 / 07期

关键词：

D O I：

10.1016/0039-9140(91)80200-J

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The uricase-like catalytic activity of the ion-exchange resins modified with metalloporphyrins has been investigated through the oxidation of uric acid. The anion-exchange resins modified with Mn3+-tetrakis(sulfophenyl)porphine and the cation-exchange resin modified with Mn3+-tetrakis(1-methylpyridinium-4-yl)porphine exhibited the highest uricase-like activity among the modified resins tested. The fact that these resins accelerated the oxidation of uric acid even after ten cycles of use indicates that the modified resins act as catalysts in the reaction catalyzed by uricase. Some of the modified resins may be effectively used for the determination of uric acid in place of uricase.

引用

页码：779 / 783

页数：5

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