THE ROLE OF SULFUR IN CEPHALOSPORIN BIOSYNTHESIS

被引:3
作者
BALDWIN, JE
GOH, KC
WOOD, ME
SCHOFIELD, CJ
COOPER, RDG
HUFFMAN, GW
机构
[1] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND
[2] LILLY CORP CTR,LILLY RES LABS,INDIANAPOLIS,IN 46285
关键词
D O I
10.1016/S0960-894X(00)80269-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The role of sulphur in cephalosporin biosynthesis was probed by evaluation of a carbocyclic analogue of deacetoxycephalosporin C as a substrate for DAOC/DAC synthase.
引用
收藏
页码:421 / 424
页数:4
相关论文
共 18 条
[1]  
BAKER BJ, 1991, J BIOL CHEM, V266, P5087
[2]   THE BIOSYNTHESIS OF PENICILLINS AND CEPHALOSPORINS [J].
BALDWIN, JE ;
ABRAHAM, E .
NATURAL PRODUCT REPORTS, 1988, 5 (02) :129-145
[3]   THE ROLE OF ALPHA-KETOGLUTARATE IN CEPHALOSPORIN BIOSYNTHESIS [J].
BALDWIN, JE ;
ADLINGTON, RM ;
SCHOFIELD, CJ ;
SOBEY, WJ ;
WOOD, ME .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (15) :1012-1015
[4]   PURIFICATION AND INITIAL CHARACTERIZATION OF AN ENZYME WITH DEACETOXYCEPHALOSPORIN-C SYNTHETASE AND HYDROXYLASE-ACTIVITIES [J].
BALDWIN, JE ;
ADLINGTON, RM ;
COATES, JB ;
CRABBE, MJC ;
CROUCH, NP ;
KEEPING, JW ;
KNIGHT, GC ;
SCHOFIELD, CJ ;
TING, HH ;
VALLEJO, CA ;
THORNILEY, M ;
ABRAHAM, EP .
BIOCHEMICAL JOURNAL, 1987, 245 (03) :831-841
[5]   SUBSTRATE-SPECIFICITY OF CLONED DEACETOXYCEPHALOSPORIN-C DEACETYLCEPHALOSPORIN C SYNTHETASE [J].
BALDWIN, JE ;
ADLINGTON, RM ;
CROUCH, NP ;
COATES, JB ;
KEEPING, JW ;
SCHOFIELD, CJ ;
SHUTTLEWORTH, WA ;
SUTHERLAND, JD .
JOURNAL OF ANTIBIOTICS, 1988, 41 (11) :1694-1695
[6]  
BALDWIN JE, 1985, RECENT ADV CHEM BETA, P62
[7]  
CHEN VJ, 1989, J BIOL CHEM, V264, P21677
[8]  
CHEN VJ, 1989, J INORG BIOCHEM, V36, pH52
[9]   COPURIFICATION AND CHARACTERIZATION OF DEACETOXYCEPHALOSPORIN-C SYNTHETASE HYDROXYLASE FROM CEPHALOSPORIUM-ACREMONIUM [J].
DOTZLAF, JE ;
YEH, WK .
JOURNAL OF BACTERIOLOGY, 1987, 169 (04) :1611-1618
[10]   THE ASYMMETRIC-SYNTHESIS OF BETA-LACTAM ANTIBIOTICS .2. THE 1ST ENANTIOSELECTIVE SYNTHESIS OF THE CARBACEPHALOSPORIN NUCLEUS [J].
EVANS, DA ;
SJOGREN, EB .
TETRAHEDRON LETTERS, 1985, 26 (32) :3787-3790