AN INVESTIGATION INTO THE ROLE OF INITIAL KLA ON THE GROWTH AND ALKALOID ACCUMULATION BY CULTURES OF CATHARANTHUS-ROSEUS

被引：34

作者：

LECKIE, F

SCRAGG, AH

CLIFFE, KC

机构：

[1] BRISTOL POLYTECH FRENCHAY,DEPT SCI,BRISTOL BS16 1Q4,ENGLAND

[2] UNIV SHEFFIELD,DEPT MOLEC BIOL & BIOTECHNOL,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

[3] UNIV SHEFFIELD,DEPT MECH & PROC ENGN,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1991年 / 37卷 / 04期

关键词：

D O I：

10.1002/bit.260370410

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effect of initial K(L)a on the batch culture of Catharanthus roseus ID1 in a 12.5-L bioreactor has been examined. Optimum K(L)a values were found for both growth and alkaloid accumulation. Different sparger designs were used to alter the K(L)a values. High K(L)a values caused increased aggregation of the cultures, depressed biomass yields, and altered patterns of alkaloid accumulation.

引用

页码：364 / 370

页数：7

共 23 条

[1]

BOYSAN F, 1988, BIOREACTOR FLUID DYN, P245

[2] GROWTH AND ACTIVITIES OF ENZYMES OF PRIMARY METABOLISM IN BATCH CULTURES OF CATHARANTHUS-ROSEUS CELL-SUSPENSION UNDER DIFFERENT PCO2 CONDITIONS [J].