A SINGLE AMINO-ACID RESIDUE DETERMINES THE CA2+ PERMEABILITY OF AMPA-SELECTIVE GLUTAMATE RECEPTOR CHANNELS

被引:65
作者
MISHINA, M [1 ]
SAKIMURA, K [1 ]
MORI, H [1 ]
KUSHIYA, E [1 ]
HARABAYASHI, M [1 ]
UCHINO, S [1 ]
NAGAHARI, K [1 ]
机构
[1] MITSUBISHI KASEI COOPERAT, RES CTR, BIOSCI LAB, YOKOHAMA 227, JAPAN
关键词
D O I
10.1016/S0006-291X(05)81137-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Functional analysis of AMPA-selective glutamate receptor channels expressed in Xenopus oocytes from cloned cDNAs has shown that homomeric channels formed by the G1uR1 subunit are permeable to Ca2+, whereas heteromeric channels composed of the GluR1 and G1uR2 subunits show little permeability. Furthermore, substitution of glutamine for arginine in putative transmembrane segment M2 of the GluR2 subunit makes the heteromeric channels permeable to Ca2+. These results suggest that the G1uR2 subunit plays a key role in keeping AMPAselective glutamate receptor channels essentially impermeable to Ca2+ and that the critical determinant is the positively charged residue in M2 segment. © 1991 Academic Press, Inc.
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页码:813 / 821
页数:9
相关论文
共 21 条
[1]   CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT [J].
BETTLER, B ;
BOULTER, J ;
HERMANSBORGMEYER, I ;
OSHEAGREENFIELD, A ;
DENERIS, ES ;
MOLL, C ;
BORGMEYER, U ;
HOLLMANN, M ;
HEINEMANN, S .
NEURON, 1990, 5 (05) :583-595
[2]   MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF GLUTAMATE RECEPTOR SUBUNIT GENES [J].
BOULTER, J ;
HOLLMANN, M ;
OSHEAGREENFIELD, A ;
HARTLEY, M ;
DENERIS, E ;
MARON, C ;
HEINEMANN, S .
SCIENCE, 1990, 249 (4972) :1033-1037
[3]   GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].
CHOI, DW .
NEURON, 1988, 1 (08) :623-634
[4]   ACTIVITY-DEPENDENT PLASTICITY IN THE VISUAL SYSTEMS OF FROGS AND FISH [J].
CLINE, HT .
TRENDS IN NEUROSCIENCES, 1991, 14 (03) :104-111
[5]   NMDA RECEPTORS - THEIR ROLE IN LONG-TERM POTENTIATION [J].
COLLINGRIDGE, GL ;
BLISS, TVP .
TRENDS IN NEUROSCIENCES, 1987, 10 (07) :288-293
[6]   CLONING OF A CDNA FOR A GLUTAMATE RECEPTOR SUBUNIT ACTIVATED BY KAINATE BUT NOT AMPA [J].
EGEBJERG, J ;
BETTLER, B ;
HERMANSBORGMEYER, I ;
HEINEMANN, S .
NATURE, 1991, 351 (6329) :745-748
[7]  
Higuchi R., 1989, PCR TECHNOLOGY PRINC, P61
[8]   CLONING BY FUNCTIONAL EXPRESSION OF A MEMBER OF THE GLUTAMATE RECEPTOR FAMILY [J].
HOLLMANN, M ;
OSHEAGREENFIELD, A ;
ROGERS, SW ;
HEINEMANN, S .
NATURE, 1989, 342 (6250) :643-648
[9]   CA2+ PERMEABILITY OF KA-AMPA GATED GLUTAMATE RECEPTOR CHANNELS DEPENDS ON SUBUNIT COMPOSITION [J].
HOLLMANN, M ;
HARTLEY, M ;
HEINEMANN, S .
SCIENCE, 1991, 252 (5007) :851-853
[10]   PERMEATION OF CALCIUM THROUGH EXCITATORY AMINO-ACID RECEPTOR CHANNELS IN CULTURED RAT HIPPOCAMPAL-NEURONS [J].
IINO, M ;
OZAWA, S ;
TSUZUKI, K .
JOURNAL OF PHYSIOLOGY-LONDON, 1990, 424 :151-165