CF-252-PLASMA DESORPTION MASS-SPECTROMETRY APPLIED TO THE ANALYSIS OF ENDOTOXIN LIPID-A PREPARATIONS

被引：29

作者：

KARIBIAN, D ^{[1
]}

DEPRUN, C ^{[1
]}

SZABO, L ^{[1
]}

LEBEYEC, Y ^{[1
]}

CAROFF, M ^{[1
]}

机构：

[1] INST PHYS NUCL, EQUIPE INTERACT ION SURFACES & MAT, F-91406 ORSAY, FRANCE

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 1991年 / 111卷

关键词：

D O I：

10.1016/0168-1176(91)85060-Y

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Negative-ion plasma desorption mass spectra of underivatized Lipid A preparations, isolated from the endotoxins of 16 Enterobacterial and non-Enterobacterial strains, are presented. These heterogeneous preparations gave signals-in the range m/z 1000-2200-characteristic of the bacterial family from which the Lipid A was obtained. Molecular compositions based on chemical analyses were attributed to the most abundant ions. The information provided makes plasma desorption mass spectrometry a powerful tool in relating Lipid A structures to their numerous biological activities. The method is rapid and requires only microgram quantities of Lipid A.

引用

页码：273 / 286

页数：14

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