CORTICAL DISTRIBUTION OF GANGLIOSIDES IN ALZHEIMERS-DISEASE

被引：98

作者：

KRACUN, I ^{[1
]}

KALANJ, S ^{[1
]}

TALANHRANILOVIC, J ^{[1
]}

COSOVIC, C ^{[1
]}

机构：

[1] CLIN HOSP M STOJANOVIC, DEPT PATHOL, VINOGRADSKA, CROATIA

来源：

NEUROCHEMISTRY INTERNATIONAL | 1992年 / 20卷 / 03期

关键词：

D O I：

10.1016/0197-0186(92)90058-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Alzheimer's disease, all ganglio-series gangliosides (GM1, GD1a, GD1b and GT1b) were found to be decreased in temporal and frontal cortex, and nucleus basalis of Meynert. In addition, in Alzheimer's disease simple gangliosides (GM2, GM3) were elevated in frontal and parietal cortex, possibly correlating to accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.

引用

页码：433 / 438

页数：6

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