DETERMINATION OF CLOZAPINE AND DESMETHYLCLOZAPINE IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET DETECTION

被引：56

作者：

CHUNG, MC

LIN, SK

CHANG, WH

JANN, MW

机构：

[1] TAIPEI CITY PSYCHIAT CTR,TAIPEI,TAIWAN

[2] MERCER UNIV,SO SCH PHARM,ATLANTA,GA 30341

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 613卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80212-M

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method using reversed-phase high-performance liquid chromatography for the simultaneous determination of clozapine and its desmethyl metabolite in human plasma has been established. Clozapine and N-desmethylclozapine were extracted with n-hexane-isoamyl aclohol (98.5:1.5, v/v). Protriptyline served as the internal standard. The limits of detection for clozapine and desmethylclozapine are 2 and 1 ng/ml, respectively. The sensitivity and precision of this method can be utilized for pharmacokinetic studies and therapeutic drug monitoring regimens.

引用

页码：168 / 173

页数：6

共 12 条

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