LOCALIZATION OF THE HUMAN INTERFERON-INDUCED, DS-RNA ACTIVATED P68 KINASE GENE (PRKR) TO CHROMOSOME-2P21-P22

被引：25

作者：

SQUIRE, J

MEURS, EF

CHONG, KL

MCMILLAN, NAJ

HOVANESSIAN, AG

WILLIAMS, BRG

机构：

[1] CLEVELAND CLIN FDN,DEPT CANC BIOL,9500 EUCLID AVE,CLEVELAND,OH 44195

[2] HOSP SICK CHILDREN,DEPT PATHOL,TORONTO M5G 1X8,ONTARIO,CANADA

[3] INST PASTEUR,VIROL & CELLULAR IMMUNOL UNIT,CNRS,UA 1157,F-75731 PARIS 15,FRANCE

来源：

GENOMICS | 1993年 / 16卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1263

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The interferon-induced dsRNA-activated protein kinase (PRKR) belongs to a subclass of serine/threonine kinases, involved in the regulation of protein synthesis by phosphorylation of the α subunit of initiation factor eIF2. Somatic cell hybrids segregating human chromosomes were used to assign this kinase to human chromosome 2. Fluorescence in situ hybridization confirmed this assignment and further localized the gene (PRKR) to the boundary region of hands p21 and 22. © 1993 Academic Press. All rights reserved.

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页码：768 / 770

页数：3

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