FUNCTIONALIZED DERIVATIVES OF HYALURONIC-ACID OLIGOSACCHARIDES - DRUG CARRIERS AND NOVEL BIOMATERIALS

被引：184

作者：

POUYANI, T

PRESTWICH, GD

机构：

[1] Department of Chemistry, University at Stony Brook, Stony Brook

来源：

BIOCONJUGATE CHEMISTRY | 1994年 / 5卷 / 04期

关键词：

D O I：

10.1021/bc00028a010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligosaccharides derived from hyaluronic acid (HA), a naturally occurring linear polysaccharide composed of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid, can be chemically modified to introduce a pendant amine-like functionality (patent application pending). Covalent attachment of steroidal and nonsteroidal antiinflammatory drugs to functionalized HA oligosaccharides was accomplished with the incorporation of hydrolytically labile bonds. Further derivatization of the pendant group with homobifunctional crosslinkers allowed the introduction of covalent crosslinks. Chemically-modified HA oligosaccharides were unambiguously characterized in solution by high-resolution H-1 NMR spectroscopy.

引用

页码：339 / 347

页数：9

共 31 条

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[Anonymous], 1986, HYDROGELS MED PHARM

[2]

Balazs E.A, 1986, OPHTHALMIC VISCOSURG, P3

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