SEQUENCE VARIATION IN THE CIRCUMSPOROZOITE PROTEIN GENE OF PLASMODIUM-VIVAX APPEARS TO BE REGIONALLY BIASED

被引：47

作者：

MANN, VH ^{[1
]}

HUANG, TY ^{[1
]}

CHENG, Q ^{[1
]}

SAUL, A ^{[1
]}

机构：

[1] GUIZHOU PROV INST PARASIT DIS,GUIYANG,PEOPLES R CHINA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1994年 / 68卷 / 01期

关键词：

PLASMODIUM VIVAX; CIRCUMSPOROZOITE PROTEIN; SEQUENCE; VARIATION;

D O I：

10.1016/0166-6851(94)00148-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have sequenced the circumsporozoite protein gene from 16 isolates from China, the Philippines, Papua New Guinea and the Solomon Islands. We found very limited polymorphisms in the non-repetitive regions of the circumsporozoite gene from these isolates. All samples from China contained a 36-base insert 3' to the repeats previously seen only in a North Korean isolate. Limited variation was found in the repeat regions, which allowed these and previously sequenced isolates to be classified into groups based on repeat structure. These groupings also correlate with the geographical origin of the isolates.

引用

页码：45 / 52

页数：8

共 17 条

[1] CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-VIVAX - GENE CLONING AND CHARACTERIZATION OF THE IMMUNODOMINANT EPITOPE [J].