SYNTHESIS AND PROPERTIES OF NOVEL BLOCK-COPOLYMERS CONTAINING POLY(LACTIC-GLYCOLIC ACID) AND POLY(ETHYLENEGLYCOL) SEGMENTS

被引：38

作者：

FERRUTI, P ^{[1
]}

PENCE, M ^{[1
]}

DADDATO, P ^{[1
]}

RANUCCI, E ^{[1
]}

DEGHENGHI, R ^{[1
]}

机构：

[1] EUROPEPTIDES GEIE,F-95100 ARGENTEUIL,FRANCE

来源：

BIOMATERIALS | 1995年 / 16卷 / 18期

关键词：

BIODEGRADATION; POLY(LACTIC-GLYCOLIC ACID); POLY(ETHYLENE GLYCOL); BLOCK COPOLYMERS;

D O I：

10.1016/0142-9612(95)96879-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha,omega-bis(chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.

引用

页码：1423 / 1428

页数：6

共 21 条

[1]

ASANO M, 1989, J CONTROL RELEASE, V9, P111

[2]

BARROWS TH, 1991, HIGH PERFORMANCE BIO, P243

[3]

BOYLE WJ, Patent No. 8905664

[4]

Casey D.J., 1987, Patents, Patent No. [4716203, US4716203A]

[5]

CHURCHILL JR, 1983, Patent No. 0092918

[6] BIODEGRADABLE PEO/PLA BLOCK COPOLYMERS [J].

COHN, D ;

YOUNES, H .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1988, 22 (11) :993-1009

[7] SYNTHESIS AND CHARACTERIZATION OF BLOCK COPOLYMERS FROM D,L-LACTIDE AND POLY(ETHYLENE GLYCOL) WITH STANNOUS CHLORIDE [J].

DENG, XM ;

XIONG, CD ;

CHENG, LM ;

XU, RP .

JOURNAL OF POLYMER SCIENCE PART C-POLYMER LETTERS, 1990, 28 (13) :411-416

[8]

FERRUTI P, UNPUB

[9]

FERRUTI P, 1993, Patent No. 2364

[10] DIRECT COPOLYMERIZATION OF L-LACTIC ACID WITH DELTA-VALEROLACTONE IN THE ABSENCE OF CATALYSTS [J].

FUKUZAKI, H ;

YOSHIDA, M ;

ASANO, M ;

AIBA, Y ;

KAETSU, I .

EUROPEAN POLYMER JOURNAL, 1988, 24 (11) :1029-1036

← 1 2 3 →