BIOSYNTHESIS OF GLYCOLIPIDS . INCORPORATION OF N-ACETYL GALACTOSAMINE BY A RAT BRAIN PARTICULATE PREPARATION

被引：44

作者：

HANDA, S

BURTON, RM

机构：

[1] Department of Pharmacology and Beaumont-May Institute of Neurology, Washington University School of Medicine, St. Louis, 63110, Missouri

来源：

LIPIDS | 1969年 / 4卷 / 06期

关键词：

D O I：

10.1007/BF02531046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mixture of UDP-(N-acetyl)glucosamine-114C and UDP-(N-acetyl)galactosamine-114C (7:3) served as a substrate to demonstrate in young rat brain tissue the presence of enzymes which catalyzes the reactions: UDP-glcNAc⇌UDP-galNAc (E.C.5.1.3) and UDP-galNAc+ gal-glc-cer→ galNAc-gal-glc-cer+UDP. The glycolipid acceptor specificity was examined and preliminary kinetic data were obtained for the UDP-(N-acetyl)galactosamine: gal-glc-ceramide N-acetyl galactosamine transferase. The products of the reaction were identified. The relationship of this reaction to ganglioside biosynthesis is discussed. © 1969 The American Oil Chemists' Society.

引用

页码：589 / &

共 44 条

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