NUCLEOSIDES OF 2-FLUOROADENINE

被引：142

作者：

MONTGOMERY, JA

HEWSON, K

机构：

[1] Kettering-Meyer Laboratory, Southern Research Institute, Birmingham

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a605

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of the anomeric 9-(2-deoxy-D-enytho-pentofuranosyl)-2-fluoroadenines and 9-D-arabinofuranosyl-2-fluoroadenines from 2,6-dichloropurine is described. The cytotoxicity of these compounds, and also of 3′-deoxy-2-fluoroadenosine and 9-β-D-xylofuranosyl-2-fluoroadenine, to a number of HEp-2 cell lines in culture has been determined. The data permit certain conclusions concerning the probable metabolism and mechanism of action of these nucleosides. © 1969, American Chemical Society. All rights reserved.

引用

页码：498 / +

页数：1

共 33 条

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