SYNTHESES OF AMINO-ACIDS AND RELATED COMPOUNDS .19. NEW VERSATILE SYNTHESES OF 2-SUBSTITUTED-2-AMINO ACID AND 2,3-DEHYDRO-2-AMINO ACID-DERIVATIVES

被引：31

作者：

OZAKI, Y ^{[1
]}

IWASAKI, T ^{[1
]}

HORIKAWA, H ^{[1
]}

MIYOSHI, M ^{[1
]}

MATSUMOTO, K ^{[1
]}

机构：

[1] TANABE SEIYAKU CO LTD,APPL BIOCHEM RES LAB,16-89 KASHIMA 3 CHOME,YODOGAWA KU,OSAKA 532,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 03期

关键词：

D O I：

10.1021/jo01317a017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Substituted-2-amino acid derivatives were synthesized in high yields by reaction of 2-acetoxy-2-amino acid derivatives, which are synthetic potential intermediates, with various nucleophiles under basic conditions. Further more, the reaction of the 2-acetoxyamino acid derivatives with a nonnucleophilic base led to the synthesis of 2, 3-dehydro-2-amino acid derivatives in excellent yields. In addition, the reaction in the presence of Lewis acid was carried out to afford the 2-substituted amino acid derivatives. © 1979, American Chemical Society. All rights reserved.

引用

页码：391 / 395

页数：5

共 18 条

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