POLYCONDENSED HETEROCYCLES .7. A CONVENIENT SYNTHESIS OF PYRROLO[1,2-A]QUINOXALINE DERIVATIVES BY INTRAMOLECULAR AROMATIC NUCLEOPHILIC DISPLACEMENT

4-(4-Methyl-1-piperazinyl)-7-trifluoromethylpyrrolo[1,2-a]quinoxaline 1a (CGS 12066B) was described in 1987 as a highly selective agonist for the serotonin sensitive receptor subtype 5-HT1B1. Although the real selectivity of 1a for 5-HT1B versus 5-HT1A binding sites has been questioned2 more recently, yet compound 1a may prove a useful tool for the identification and the characterization of the putative receptor subtypes.