PITUITARY SIZE IN DEPRESSION

被引：160

作者：

KRISHNAN, KRR

DORAISWAMY, PM

LURIE, SN

FIGIEL, GS

HUSAIN, MM

BOYKO, OB

ELLINWOOD, EH

NEMEROFF, CB

机构：

[1] DUKE UNIV, MED CTR, DEPT RADIOL, DURHAM, NC 27710 USA

[2] DUKE UNIV, MED CTR, DEPT PHARMACOL, DURHAM, NC 27710 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1991年 / 72卷 / 02期

关键词：

D O I：

10.1210/jcem-72-2-256

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

引用

页码：256 / 259

页数：4

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