A FURTHER EXPLORATION OF THE RELATIONSHIPS BETWEEN IMMUNE PARAMETERS AND THE HPA-AXIS ACTIVITY IN DEPRESSED-PATIENTS

被引：60

作者：

MAES, M ^{[1
]}

BOSMANS, E ^{[1
]}

SUY, E ^{[1
]}

MINNER, B ^{[1
]}

RAUS, J ^{[1
]}

机构：

[1] DR WILLEMS INST,DIEPENBEEK,BELGIUM

来源：

PSYCHOLOGICAL MEDICINE | 1991年 / 21卷 / 02期

关键词：

D O I：

10.1017/S0033291700020419

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to the mitogens Phytohaemagglutinin (PHA), Pokeweed (PWM) and Concanavalin A (Con A) and 8 a.m. baseline cortisol values in plasma, free cortisol excretion in 24 h urine (UFC), basal and post-dexamethasone beta-endorphin values. Major depressed patients with melancholia/psychotic features exhibited a significantly lower mitogen-induced blast transformation as compared to minor and simple major depressed patients. The lymphocyte responses to the three mitogens were significantly inversely related to baseline cortisol values and postdexamethasone beta-endorphin values. The proliferative capacity of lymphocytes to stimulation with PHA and PWM was significantly and positively related to UFC excretion. Up to 45 % of the variance in the immune responses to the mitogens was explained by the baseline cortisol, postdexamethasone beta-endorphin and UFC values.

引用

页码：313 / 320

页数：8

共 70 条

[1] A CONTROLLED-STUDY OF CELLULAR IMMUNE FUNCTION IN AFFECTIVE-DISORDERS BEFORE AND DURING SOMATIC THERAPY [J].