HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD USING ULTRAVIOLET DETECTION FOR MEASURING METRIFONATE AND DICHLORVOS LEVELS IN HUMAN PLASMA

被引：17

作者：

UNNI, LK

HANNANT, ME

BECKER, RE

机构：

[1] Neurochemistry Laboratory, Department of Psychiatry, Southern Illinois University School of Medicine, Springfield

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 573卷 / 01期

关键词：

D O I：

10.1016/0378-4347(92)80480-E

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report high-performance liquid chromatographic methods using ultraviolet detection, developed for the first time in our laboratory with sensitivity to detect clinically significant concentrations of metrifonate (MTF), an experimental drug for Alzheimer disease, and its active anticholinesterase metabolite, dichlorvos (DDVP). The determination limit of the method for MTF and DDVP was 1-mu-g/ml and 40 ng/ml, respectively. Stability of MTF and DDVP at various temperatures in water, buffered solutions and in human plasma were also studied.

引用

页码：99 / 103

页数：5

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