PHOSPHOLIPASE-B CONTENT OF THE INTESTINES OF SENSITIZED RATS CHALLENGED WITH VARIED LARVAE DOSES OF NIPPOSTRONGYLUS-BRASILIENSIS

The effects of challenging previously infected (sensitized) groups of rats with 25, 100 and 400 Nippostrongylus brasiliensis larvae on the relation between phospholipase B activity, bone marrow eosinophilia and worm burden were studied. The results indicated that the immune expulsion of worms from sensitized rats was temporally related to an increased phospholipase B activity and bone marrow eosinophilia. All three parameters demonstrated an anamnestic-type of response in the previously infected rats when compared to the infected control animals. The results also demonstrated that the size of the worm burden influenced the induction and concentration of phospholipase B and the numbers of bone marrow eosinophilis. © 1979.